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Action of the First Component of Complement

Activation of C'1 to C'1a in the Hemolytic System

From the Immunology Section, Diagnostic Research Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland

Abstract

The interaction of SAC'4 with guinea pig or human C'1 as they exist in whole serum yields an intermediate designated SAC'1,4. This intermediate is activated to SAC'1a,4 even in the absence of fluid phase serum factors at a rate which is dependent on temperature.

Partially purified guinea pig C'1 was found to be in the activated state (C'1a) while partially purified human C'1 was found to be in the precursor form.

Footnotes

¹ This work was begun at the Department of Microbiology, Johns Hopkins University School of Medicine during the tenure of a Career Development Fellowship, United States Public Health Service. It was supported by ONR Contract Nonr 248(60) NSF Grant G19372 and NIH Grant AI 2566.

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