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Demonstration of Two Types of Low Molecular Weight -Globulins in Normal Human Urine¹

From the Department of Medicine, Columbia University College of Physicians and Surgeons, and Francis Delafield Hospital, New York, New York

Abstract

Low molecular weight -globulins in normal human urine (-u) are antigenically related to the S fragment of papain-digested ₂-globulin and have thermosolubility properties similar to those of Bence Jones proteins.

By immunodiffusion techniques, it has been established that there are at least two distinct populations of -u, designated -uA and -uB, which are respectively related to the Korngold and Lipari type A (= Mannik and Kunkel group 2) and Korngold and Lipari type B (= Mannik and Kunkel group 1) Bence Jones proteins.

The low molecular weight -u-globulins are increased in patients with various diseases associated with hypergammaglobulinemia and diminished in patients with hypogammaglobulinemia.

Footnotes

¹ Presented in part at the Annual Meeting of the American Association of Immunologists, Atlantic City, New Jersey, April 1963.

Supported by an institutional grant of the National Cancer Institute (CY 2332).

² Research Trainee of the National Cancer Institute, United States Public Health Service (CRTY 5011).

³ Faculty Research Associate of the American Cancer Society.