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Methotrexate Inhibition of Tuberculin Hypersensitivity in Inbred Guinea Pigs

From the United States Department of Health, Education and Welfare, Public Health Service, National Institutes of Health, National Cancer Institute, Pathologic Anatomy Branch, and the National Institute of Allergy and Infectious Diseases, Laboratory of the Biology of Viruses, Bethesda, Maryland

Abstract

Methotrexate has been employed to inhibit the development of tuberculin hypersensitivity in strain 2 guinea pigs. Tuberculin hypersensitivity is transferred in these animals with viable isologous lymph node cells. The results of experiments employing such lymph node transfers suggested the drug was not acting on the inductive phase of the immune response but on the proliferation of immunologically active cells.