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Tolerance to a Protein Antigen in Adult Mice and the Effect of Nonspecific Factors¹

From the Department of Medicine, University of Colorado School of Medicine, Denver, Colorado

Abstract

1. Immunologic tolerance was induced in adult CBA mice by a single injection of the supernatant from ultracentrifuged bovine -globulin (BGG). Mice so treated and later challenged with BGG-Bentonite did not produce detectable antibody as measured by the disappearance rate of I¹²⁵ BGG or by the microhemagglutination method.

2. The sediment from pooled ultracentrifuged BGG induced antibody formation rather than tolerance.

3. Tolerance could be produced by as little as 0.19 mg of supernatant BGG. Such tolerance could be partially overcome by 19 mg, but not by 1.9 mg of BGG-Bentonite. Partial tolerance was induced by 0.019 mg of supernatant BGG.

4. Tolerance could not be produced by supernatant BGG when it was accompanied by an intravenous dose of 100 µg of bacterial endotoxin.

Footnotes

¹ This work was supported in part by the Burroughs Wellcome Company and by United States Public Health Service Research Grant AI-03047.

² Burroughs Wellcome Fellow in Allergy.

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