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Phylogeny of the Immune Response

Studies on Some Physical Chemical and Serologic Characteristics of Antibody Produced in the Turtle^{1 ,2}

From the Division of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California

Abstract

The immune response of turtles to giant keyhole limpet hemocyanin was studied by means of the precipitation of I*-hemocyanin by antiserum. The pertinent findings were:

1. The 18 S protein constitutes 13 to 26% of the total normal serum protein in the turtle.

2. In an antibody response rapidly sedimenting antibody predominates for the first month and is gradually replaced by slowly sedimenting antibody.

3. The slowly sedimenting antibody activity as well as that of the rapidly sedimenting antibody activity is almost entirely destroyed by 2-mercaptoethanol treatment.

4. No anamnestic response occurred.

5. The precipitin reaction between turtle antibody and antigen remains, throughout the course of immunization, similar to a mammalian primary response in that it is greatly effected by dilution of the test system.

Footnotes

¹ This is publication number 47 from the Division of Experimental Pathology, Scripps Clinic and Research Foundation. Submitted June, 1963.

² This work was supported in part by United States Public Health Service grants and an Atomic Energy Commission contract.

³ Present address: Rockefeller Institute, New York 21, New York.

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