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The Common Protein Agglutinogen of Staphylococcus Aureus

I. Distribution in International Serotypes and Corresponding Antibody in Human Populations¹

From the United States Veterans Administration Hospital and Department of Public Health and Preventive Medicine, University of Pennsylvania, Philadelphia, Pennsylvania

Abstract

A protein agglutinogen common to the internationally recognized serotypes of Staphylococcus aureus is described. Sera of all human subjects studied, healthy or infected, possess a high and fairly uniform level of antibodies against this agglutinogen. The agglutinin is concentrated in commercial human -globulin and is deficient in the blood of agammaglobulinemic children. No immunizing agent has been found which will regularly increase agglutination titers in man to a significant degree, although some increase has been induced in rabbits. Serum absorbed with the pure protein agglutinogen shows decreased agglutination titer against all serotypes but is not deprived of its phagocytosis promoting power.

Footnotes

¹ This work was supported by a grant from the Veterans Administration Central Office Research Service, Washington, D. C., and Research Grant E-2690 from the National Institutes of Health, Bethesda, Maryland.

² Present address: Laboratory of Molecular Biology, National Institute of Neurological Diseases and Blindness, National Institutes of Health, Bethesda 14, Maryland.