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The Journal of Immunology, 1963, 91: 740-747.
Copyright © 1963 by The American Association of Immunologists, Inc.
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Species Specificity of Globulins in Reactions with Rheumatoid Arthritis Serum1

Robert M. Pike and Mary Louise Schulze

From the Department of Microbiology, The University of Texas Southwestern Medical School, Dallas, Texas

Abstract

Sheep cells sensitized with subagglutinating amounts of chicken antisheep cell serum were not agglutinated in RAS. Chicken antibody globulin attached to sheep cell stromas and in the form of an immune precipitate failed to absorb from RAS the factor responsible for the agglutination of sheep cells sensitized with rabbit antibody, whereas rabbit antibody did remove this factor under comparable circumstances. Neither chicken nor rabbit antibody globulin absorbed the factor causing the agglutination of latex particles coated with human {gamma}-globulin.

Normal chicken {gamma}-globulin used to coat tanned sheep cells and latex particles reacted with RAS to a degree comparable to that of normal rabbit {gamma}-globulin, but was less reactive than normal human {gamma}-globulin. Chicken {gamma}-globulin failed to inhibit completely the agglutination by RAS of sheep cells sensitized with rabbit antibody, although human {gamma}-globulin was inhibitory in relatively high concentrations as compared to the low concentration of rabbit {gamma}-globulin required to inhibit.

These observations are discussed in relation to the existence of multiple rheumatoid factors of differing specificities.

Footnotes

1 Supported by Grant G21,472 from the National Science Foundation.






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