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Evaluation of Indirect Fluorescent Antibody Technique for Detection of Rabies Antibody in Human Sera

From the CDC Rabies Investigations Laboratory, Communicable Disease Center, Public Health Service, U. S. Department of Health, Education and Welfare, Atlanta, Georgia

Abstract

Five hundred and eighty-eight sera were tested by the serum neutralization (SN) and indirect fluorescent rabies antibody (IFRA) procedures. Of 285 positive sera by the SN test, 280 (98.3%) were also positive by the IFRA method, indicating acceptability of the IFRA test as a screening procedure for the detection of rabies antibody. Seventy-eight sera from rabies-immunized people were positive by the IFRA method and negative by the SN method, indicating a greater sensitivity of the IFRA test. Further investigations are needed to define the relationship of demonstrable rabies antibody to protection against rabies virus challenge.