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Antigenic Relationship between Two Types of 7 S Guinea Pig -Globulins¹

From the Department of Pathology, New York University School of Medicine, New York, New York

Abstract

The antigenic relationship between isolated guinea pig 7 S ₁ and ₂ antibodies has been examined. The two -globulins cross-react when studied with rabbit antisera to whole guinea pig serum in immunoelectrophoresis and Ouchterlony plates. Absorption of rabbit antisera with the slow fragment of guinea pig -globulin, obtained by starch block electrophoresis of papain digest, removes this cross-reactivity. It is concluded that the known differences in biologic activities of these two types of -globulins must be due to different structures of the H chain.

Isolated guinea pig antibodies of various antihapten specificities show consistent differences in their immunoelectrophoretic patterns with respect to mobility and number of precipitation arcs observed. Some of the differences have been shown to reside in the slow fragment. However, no qualitative antigenic differences have thus far been shown by absorption studies of the rabbit antisera used.

Footnotes

¹ Supported by the United States Public Health Service under Grants AI-04983 and AI-3076, and the Health Research Council of the City of New York under contract Nos. I-138 and I-140.

² Recipient of a Career Development Award, No. 5-K3-GM-15522-03, from the United States Public Health Service.