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The Development of Infectivity, Antigens and Particles in Herpes Infected Cells

From the Institute of Virology, The University, Glasgow, W.2, Scotland

Abstract

The growth of herpes virus in HeLa cells and BHK21 cells has been studied.

1. Virus specific antigen(s) appeared earlier than new virus particles.

2. Throughout the growth cycle more than 80% of the antigens could be separated from virus particles by centrifugation.

3. There was a consistent alteration in the particle: infectivity ratio with time; early virus had high ratios.

Footnotes

¹ Fellow, USPHS (Fellowship 17-146). On sabbatical leave during the period of time this work was done from the Department of Pediatrics, Western Reserve University School of Medicine and Cleveland Metropolitan General Hospital, Cleveland, Ohio.

² Members of the Medical Research Council Experimental Virus Unit, Glasgow.