HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Amkraut, A. A. Articles by Raffel, S. Search for Related Content PubMed PubMed Citation Articles by Amkraut, A. A. Articles by Raffel, S.

Elicitation of PCA by Univalent and Divalent Haptens¹

From the Department of Medical Microbiology, Stanford University School of Medicine, Stanford, California

Abstract

PCA reactions were obtained using anti-DNP antisera and "univalent" haptens containing only a single DNP group. Antisera prepared against different DNP-antigens differed in their capacities to react with the various compounds used, a fact which supports the contention that compounds containing two DNP groups act functionally as univalent haptens.

The characteristics of the reaction are described, and a possible mechanism is proposed which relates the reaction to the "toxic" nature of the unbound portion of the hapten and the relative persistence of hapten-antibody complexes.

Footnotes

¹ This investigation was supported by Public Health Service training grant 2E-82 and research grant AI-04442, from the National Institute of Allergy and Infectious Diseases, USPHS, and by predoctoral Fellowship GF-12,375 from the Division of General Medical Sciences, USPHS.

² Now in the Division of Chemistry, California Institute of Technology, Pasadena, California.