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Alteration of the Specificity of Lectin by Chemical Modification¹

From the Boston University School of Medicine, Boston, Massachusetts

Abstract

What is thought to be the first instance of the modification of the specificity of a lectin by chemi-treatment is reported. Coupling diazotized p-aminophenyl - N - acetyl - D - galactosaminide to anti-A lima bean lectin greatly increased the agglutinating power of the lectin for group B cells without significantly altering its agglutinative activity for A₁, A₂, or O cells. The question is raised; do these observations possibly point to a role of carbohydrates in the specificity of lectins (and possibly of antibodies)?

Footnotes

¹ The research reported in this paper was supported by Research Grants H-1076 (C8), RG-4704 (C4), and RG-6939 (C4) from the National Institutes of Health and a research grant, NSF-G-15082, from the National Science Foundation. William C. Boyd is the recipient of a National Institutes of Health Research Career Award (5-K6-GM-14,184-02).