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Immunochemical Studies on Dextrans

III. The Specificities of Rabbit Antidextrans. Further Findings on Antidextrans with 1,2- and 1,6-Specificities^{1 ,2}

From the Departments of Microbiology and Neurology, College of Physicians and Surgeons, Columbia University and the Neurological Institute, Presbyterian Hospital, New York

Abstract

Antidextrans produced by rabbits resemble corresponding human antidextrans. Inhibition data indicate that most of the combining regions of antibody in the rabbit sera studied are complementary to chains of not more than five or six hexose units. Dextrans known to contain a high proportion of 1,2-linkages cross-react 85 to 100% with human and rabbit antibodies to dextran 1424, which has an unknown content of 1,2-linkages, thus confirming previous immunochemical inferences that this dextran is also highly 1,2-linked. Inhibition data also support this conclusion.

Footnotes

¹ Aided by grants from the National Science Foundation (G-18727) and General Research Support Grant of the National Institutes of Health, U. S. Public Health Service.

² Part I of a thesis submitted by Rose G. Mage in partial fulfillment of the requirements for the degree of Doctor of Philosophy, in the Faculty of Pure Science, Columbia University.

³ National Science Foundation Predoctoral Fellow 1956–1959.