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Differential Effects of Specific Antisera on the Rejection of Allogeneic and Xenogeneic Skin Grafts by Sublethally X-Irradiated Mice¹

From the Biological and Medical Sciences Division, U. S. Naval Radiological Defense Laboratory, San Francisco 24, California

Abstract

Data are presented indicating that the first-set response to an allogeneic skin graft can be significantly inhibited in sublethally irradiated mice by passively transferred specific antisera, whereas, in contrast, the first-set response to a xenogeneic skin graft remains resistant to similar treatment. Specific antisera had no effect upon a pre-existing second-set response.

Footnotes

¹ This study was supported through funds provided by the Bureau of Medicine and Surgery, U. S. Navy Department. The opinions and assertions contained herewith are those of the authors and are not to be construed as official or as reflecting the views of the Navy Department.