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Anti-Bovine Serum Albumin Formation by Transferred Hyperimmune Mouse Spleen Cells^{1 ,2}

From the Division of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California

Abstract

Antibody formation by transferred hyperimmune spleen cells has been studied with bovine serum albumin as antigen and inbred mice as donors and recipients. It has been shown that isologous adult and neonatal hosts support antibody formed in neonatal hosts was less than that in adult recipients. Antibody was not formed in homologous adult or newborn recipients and this is most likely because of rejection of the transferred cells prior to their formation of antibody. The host vs. graft reaction could be suppressed by prior x-irradiation of recipients with consequent antibody formation by transferred homologous cells. Further, if isologous recipients were irradiated prior to cell transfer, the antibody response was found to be greater than that in nonirradiated isologous hosts. Transferred cells appeared to survive in the isologous recipients for a prolonged period of time with continuing formation of antibody.

Footnotes

¹ Presented in part at the 1962 meeting of the Federation of American Societies for Experimental Biology, April 14–18, 1962, Atlantic City, N. J.

² This is publication number 41 of the Division of Experimental Pathology, Scripps Clinic and Research Foundation, La Jolla, California; the work was supported by a USPHS grant and an AEC contract.

³ Supported by a USPHS training grant; present address: Immunogenetics Research Unit, Duke University Medical Center, Durham, North Carolina.