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Quantitative Determination of 6.6 S -Globulins, _2A-Globulins and ₁-Macroglobulins in Human Serum

From the Metabolism Service, National Cancer Institute, National Institutes of Health, Bethesda 14, Maryland

Abstract

The serum levels of 6.6 S -globulins, _2A-globulins and ₁-macroglobulins were determined by quantitative immune inhibition techniques. The 6.6 S -globulins, with an average serum level of 12.63 mg/ml, were found to constitute about 71% of the total serum -globulins. The _2A-globulins comprise about 22% of the -globulins (average serum level of 3.94 mg/ml). The ₁-macroglobulins account for about 7% of the serum -globulins (average value 1.16 mg/ml). The relative electrophoretic mobility of the -globulin groups was determined. The electrophoretic heterogeneity of each group was confirmed. Most of the 6.6 S -globulins were in the -globulin region, although some migrated more rapidly. The ₁-macroglobulins were intermediate in mobility and the _2A-globulins, as a group, migrated most rapidly.

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				J. L. Fahey and H. Goodman Antibody Activity in Six Classes of Human Immunoglobulins Science, February 7, 1964; 143(3606): 588 - 589. [Abstract] [PDF]