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Studies on Delayed Hypersensitivity to Proteins and Protein Conjugates¹

From the Departments of Biochemistry and Microbiology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania

Abstract

Picrylation of -globulins suppresses both their ability to induce delayed hypersensitivity and anaphylaxis to the carrier protein in guinea pigs. Furthermore, picrylation decreases the reactivities of the test antigens in both systems. These data provide no evidence for a dissociation between the antigenic sites responsible for antibody production and delayed hypersensitivity.

Difficulties inherent in the application of chemically altered proteins to studies of this type have been emphasized.

Footnotes

¹ This study was aided by Public Health Service research grants, A-727 from the National Institute of Arthritis and Metabolic Diseases, AI 03561 from the National Institute of Allergy and Infectious Diseases, and by the Office of Naval Research under contract 1833 (00), NR 101-412.