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Studies on Immune Human Hemolysis

III. Role of 11 S Component in Initiating the Donath-Landsteiner Reaction¹

From the Western Reserve University School of Medicine, Cleveland 6, Ohio

Abstract

1. The 11 S component of normal human serum is required in the initial cold phase of the Donath-Landsteiner reaction, an autoimmune hemolytic reaction entirely of human origin.

2. The 11 S component is present in crude preparations of C'1-esterase, and removal of 11 S renders C'1-esterase inactive in the cold phase of the reaction.

3. The 11 S component precedes C'1-esterase in the initiation of the hemolytic reaction, and, in contrast to C'1-esterase, is not inhibited by Na₃HEDTA or serum inhibitor of C'1-esterase.

Footnotes

¹ Presented in part at the 54th annual meeting of the American Society of Clinical Investigation, Atlantic City, N. J., April 29, 1962; supported in part by Grant H 1263C, National Heart Institute, National Institutes of Health, USPHS.

² John and Mary R. Markle Scholar in Academic Medicine.