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Structural Basis for the Differences between Type I and Type II Human -Globulin Molecules

From the Metabolism Service, National Cancer Institute, National Institutes of Health, Bethesda 14, Maryland

Abstract

Polypeptide chains common to all -globulin groups (i.e., 6.6 S -globulins, _2A-globulins, ₁-macroglobulins, and -microglobulins) were found in two forms (I and II) differing in antigenic composition. The two types of common polypeptides were characterized as "L" chains with a molecular weight of about 20,000.

Each 160,000 molecular weight human -globulin molecule appears to be composed of two "L" polypeptide chains with identical (type I or II) antigenic properties (which account for 25% of the molecule) and class specific (, _2A or _1M-type) "H" components (which account for the remaining 75% of the molecule).

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