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Mechanisms of Immunologic Paralysis by Pneumococcal Polysaccharide

II. The Influence of Nonspecific Factors on the Immunity of Paralyzed Mice to Pneumococcal Infection¹

From the Department of Medical Microbiology, University of Wisconsin, Madison 6, Wisconsin

Abstract

Immunologic paralysis by type I pneumococcal polysaccharide could be terminated with water-in-oil emulsion 14 days after its induction. Mice were not immunologically paralyzed by 500 µg of pneumococcal polysaccharide if water-in-oil emulsion was inoculated simultaneously, 2 hr after, or 2 days before. Resistance resulting from adjuvant alone was observed but was of a lower order of magnitude than that produced by adjuvant in paralyzed mice.

Large numbers of murine splenic and exudative cells failed to break paralysis. Paralyzed mice were made resistant to pneumococcal infection by injection of a suspension of normal splenic cells containing 0.5 µg of polysaccharide, but these results could not be regularly repeated.

Footnotes

¹ This investigation was supported in part by a traineeship, 2E-85, from the National Institute of Allergy and Infectious Diseases, U. S. Public Health Service.

² United States Public Health Service Postdoctoral Fellow, EPD-16,821.