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Mechanisms of Immunologic Paralysis by Pneumococcal Polysaccharide

I. Studies of Adoptively Acquired Immunity to Pneumococcal Infection in Immunologically Paralyzed and Normal Mice¹

From the Department of Medical Microbiology, University of Wisconsin, Madison 6, Wisconsin

Abstract

Normal mice and mice immunologically paralyzed with type I pneumococcal polysaccharide were adoptively immunized by transfer of splenic cells from immune mice. In contrast, splenic cells from paralyzed mice were incapable of adoptively immunizing normal mice.

Footnotes

¹ This investigation was supported in part by a traineeship, 2E-85 from the Natioinal Institute of Allergy and Infectious Diseases, U. S. Public Health Service.

² United States Public Health Service Postdoctoral Fellow, EPD-16,821.