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Adenovirus Vaccine Prepared by Thermal Inactivation of the Infective Molety of the Virus in Magnesium Ions¹

From the Department of Virology and Epidemiology, Baylor University College of Medicine, Houston, Texas

Abstract

MgCl₂-inactivated adenovirus vaccine (type 7) was prepared by heating at 50°C for 30 min, six times longer than necessary to inactivate the infective moiety of the virus. The vaccine proved to be as antigenic in rabbits as the live virus, producing the same neutralizing and complement-fixing antibody titers. Infectivity could not be restored by removal of the MgCl₂ through dialysis.

Footnotes

¹ Aided by a training grant (2E-74) from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, United States Public Health Service.

² Visiting Fellow of the China Medical Board.