HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Gill, T. J. Articles by Dammin, G. J. Search for Related Content PubMed PubMed Citation Articles by Gill, T. J., III Articles by Dammin, G. J.

Studies on Synthetic Polypeptide Antigens

X. The Skin Reactivity of Actively Immunized Rabbits¹

From the Laboratory of Chemical Pathology, Department of Pathology, Harvard Medical School and Peter Bent Brigham Hospital, Boston, Massachusetts

Abstract

The majority of the skin reactions in rabbits immunized with a variety of synthetic polypeptide antigens which elicited the production of circulating antibody were the classical active Arthus reactions (Arthus type I). However, the polypeptide preparation Glu₅₆Lys₄₃Tyr₁-1 elicited a skin reaction which followed the course of the delayed, or tuberculin, reaction despite the fact that it elicited the production of circulating antibody (Arthus type II). On the basis of the skin reactions elicited by the various synthetic polypeptides, the hypothesis was advanced that the character and intensity of the skin reactions are determined in part by the amino acid composition of the antigen.

Footnotes

¹ This work was supported by grants from the National Heart Institute (H-1771, HTS-5274) and by a contract with the United States Army Medical Research and Development Command (MD-2061).

² Recipient of a Lederle Medical Faculty Award (1962-1965). During part of the study this author was a Junior Fellow of the Society of Fellows, Harvard University.