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Biologic Activity of Soluble Antigen-Antibody Complexes

VIII. Complexes of Chicken Antibodies¹

From the National Institute of Health, Tokyo, Japan and Children's Asthma Research Institute and Hospital, Denver, Colorado

Abstract

Skin reactivity and complement-fixing properties of soluble antigen-chicken antibody complexes were studied. It was found that the soluble complexes composed of rabbit -globulin induced skin reactions in normal guinea pigs. Chicken antibody directed toward the major rabbit -globulin antigenic determinant in Fr. III segment and that to the minor determinant in Frs. I and II (Porter's terminology) are comparable with respect to the ability to form skin reactive complexes. The complexes composed of either bovine serum albumin or Fr. (I + II) and homologous chicken antibodies failed to give the skin reaction. The results indicated the parallelism between the skin reactivity of the soluble complexes and the reversed passive cutaneous anaphylaxis reactions with the antigen-antibody systems.

The soluble complexes of chicken antibody did not inactivate a significant amount of guinea pig complement in vitro.

Footnotes

¹ This work was supported by Research Grants E-3308 and Al-04985 from the National Institute of Allergy and Infectious Diseases, U. S. Public Health Service.

² Present address: Children's Asthma Research Institute and Hospital, Denver, Colorado.