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Transfer of Neutralizing Antibody by Colostrum to Calves Born of Foot-and-Mouth Disease Vaccinated Dams

From the Plum Island Animal Disease Laboratory, Animal Disease and Parasite Research Division, ARS, U. S. D. A., Greenport, Long Island, New York

Abstract

The transfer of neutralizing antibody to calves born of dams vaccinated against foot-and-mouth disease was by colostrum only. Immunoelectrophoretic study showed that calves were born with no -globulin in the serum, but that it was present 2 hr after they ingested colostrum. Transfer of neutralizing antibody could be blocked by prior feeding of skim milk or immune bovine serum. A passively immune calf did not respond to vaccination until the serum antibody reached low levels; whereas, a calf of the same age born of a nonimmune dam could be vaccinated as evidenced by the production of neutralizing antibody.