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Interference and Interferon in Persistent Viral Infections of Cell Cultures¹

From the Virus Laboratories at the Children's Hospital of Philadelphia and the School of Medicine, University of Pennsylvania

Abstract

It may not come as a surprise that the subject of this address is concerned with viral interference, since interference phenomena have provided a sort of Leitmotif, with variations, for my laboratory during the past 20 years. It was introduced in 1942 by the repeated loss of the then new influenza B virus on serial transfers in the chick embryo which, rightly or wrongly, was ascribed by my wife and myself to interference by inactive virus particles accumulating in preceding passages under unfavorable conditions (1). To be sure, experimentally inactivated influenza virus particles were found to interfere with the propagation of various viruses in the chick embryo allantois and this and other systems of interference ever since have supplied problems for study, by design or by chance. Of late, interference entered again in the analysis of persistent viral infections of cultured cell populations, a problem which has received considerable attention in recent years because of its possible bearing, among others, on latent viral infections in intact hosts.

Footnotes

¹ Presidential Address to the American Association of Immunologists, April 17, 1963.

The recent, as yet unpublished experiments included in this report were supported by Grant C-4568 from the National Cancer Institute and Grant E-2405 from the National Institute of Allergy and Infectious Diseases, United States Public Health Service.