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Studies on Systemic Reactivity to Purified Protein Derivative (PPD) and Endotoxin¹

II. Systemic Reactivity to Endotoxin in Pyridoxine-Deficient Guinea Pigs and Its Relationship to Systemic Reactivity to PPD

From the Departments of Microbiology and Biochemistry, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania

Abstract

Pyridoxine-deficient guinea pigs, immunized with bacillus Calmette-Guérin (BCG) or nonimmunized, showed unaltered reactivity to endotoxin when compared to guinea pigs fed diets adequate in pyridoxine. A comparison between this unaltered reactivity to endotoxin and the depressed reactivity to purified protein derivative (PPD) in this deficiency state reported previously (1, 2) allows the conclusion that differences in basic mechanisms must be involved.

Footnotes

¹ This study was aided by Public Health Service research grants, E-3561 from the National Institute of Allergy and Infectious Diseases and A-727 from the National Institute of Arthritis and Metabolic Diseases, and by the Office of Naval Research under Contract 1833 (00), NR 101-412.