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Studies on the Immune Globulins of Human Serum

II. A Study of the Distribution of Anti-Brucella and Anti-Diphtheria Antibody Activities among _ss-, _1M- and _1A-globulin Fractions¹

From the Department of Internal Medicine A Cliniques Universitaires St. Pierre, Louvain, Belgium, and the Institute of Bacteriology, University of Louvain, Belgium

Abstract

The serum of a subject vaccinated with diphtheria toxoid and two sera from patients recovering from infections with Brucella abortus suis were fractionated and samples consisting of _ss- (7 S ), _1M- (19 S ) and _1A- (_2A-) globulins were separately assessed for antibody activity. All three protein species appeared to be serologically active.

Particular care was taken with the interpretation of data concerning the _1A-globulin samples. The serologic activities of the _1A samples could not be explained on the basis of any contamination with _ss-globulin, and were ascribed to _1A-globulin itself. A peculiar feature of the _1A anti-Brucella agglutinins here studied was their absence of complement-fixing capacity.

It is suggested that future investigations on the physicochemical nature of antibodies be carried out with the knowledge that _1A- (_2A-) globulin constitutes a third class of antibodies, besides the _ss- (7 S ) and _1M- (19 S ) classes.

Footnotes

¹ This investigation was supported by Public Health Service Grant A-4263 (C1) from the United States Department of Health, Education and Welfare, and by Grant 270 from the Fonds de la Recherche Scientifique Médicale, Brussels, Belgium.

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