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The Journal of Immunology, 1963, 91: 100-106.
Copyright © 1963 by The American Association of Immunologists, Inc.
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Antibody, Lysozyme and Complement Levels in Animals Chemically Protected against X-Irradiation1

William A. Hook, Andre J. Toussaint and Louis H. Muschel2

From the Department of Serology, Division of Communicable Disease and Immunology, Walter Reed Army Institute of Research, Walter Reed Army Medical Center, Washington, D. C.

Abstract

Various chemicals have been found to protect animals against the lethal effects of x-rays when administered before irradiation. Substances creating anoxia and chemicals containing sulfhydryl (-SH) groups are among those discovered to be capable of protecting against doses of the LD50 to LD100 range (2). The effect of x-rays on the immune mechanism of mice given a protective chemical containing -SH groups was studied by Makinodan et al. (3) who found that the rate of recovery of the antibody forming mechanism in animals given 950 r and protected with 2-mercaptoethylguanidine hydrobromide (MEG) was approximately equivalent to the rate for mice given 475 r without protection. Their results indicated that -SH compounds such as MEG do not specifically protect antibody forming cells but aid the animal by acting as "dose reducing" agents. Irradiation has been shown also to cause a decline in levels of natural hemagglutinins (4), natural hemolytic antibodies (5), and bactericidal constituents of serum (6, 7).

Footnotes

1 A preliminary report was read at the 1960 Meeting of the American Association of Immunologists (1).

2 Present address: Department of Microbiology, Medical School, University of Minnesota, Minneapolis 14, Minnesota.






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