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Protection of Mice against Irradiation and Tetanus by Homologous Bone Marrow Cells from Hyperimmunized Donors¹

From the Department of Medicine, Jefferson Medical College, Philadelphia, Pennsylvania

Abstract

Aside from irreversible damage to certain organs, such as the lens of the eye and the gonads, animals treated with lethal doses of whole body x-irradiation and protected by isologous bone marrow survive long periods without special care. Those animals protected by homologous bone marrow and other homologous tissues may have a different fate (1). The difference in mortality observed has been related to the histocompatability genes possessed by donor and host as described by Counce et al. (2). This situation is simplified when skin grafts are exchanged between a variety of inbred mice. In such experiments homologous skin grafts between mice that possess the same H₂ genes remain viable for longer periods than homologous grafts between mice from different H₂ groups (2). When homologous marrow is infused into an irradiated host the situation is more complicated; after surviving the acute effects of total body irradiation, the mice experience a second period of weight loss followed in some instances by dermatitis, diarrhea and death.

Footnotes

¹ This work was supported by grants from the National Institutes of Health, CA 04100-05 and the Atomic Energy Commission, AT(30-1)-2862.