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The Resistance of A2G Mice to Myxoviruses

From the Swiss Federal Office of Public Health, Berne, Switzerland, and the University of Sheffield Virus Research Laboratory, Sheffield, Great Britain

Abstract

Inbred A2G mice were found to be more resistant than other laboratory mice with respect to the following viral infections: neurotropic influenza A virus given intracerebrally (strains NWS, WSNF and Neuro-Kunz) and intranasally (strains NWS and WSNF); pneumotropic influenza A virus given intranasally (strains Swine, WS and PR8); and Sendai parainfluenza 1 virus given intranasally. Two mouse-adapted strains of Asian influenza (A/Singapore/1/57) were the only myxoviruses studied to which there was no difference in susceptibility between A2G and control animals.

Not many more virus particles were required to initiate neuro-infection in A2G mice as compared to control mice. Virus titers reached in the brains after inoculation of neurotropic influenza virus were 100 times lower in A2G mice; similarly, 100 times less virus was recovered from lungs of A2G mice inoculated with Lee influenza B virus of low mouse virulence.

No differences were found in the susceptibility to the toxic action of influenza A virus between A2G and control animals. After comparable inocula of influenza A virus given intranasally, A2G mice developed lower levels of hemagglutination-inhibiting and complement-fixing antibodies than did surviving controls.

A2G and control mice proved equally susceptible to the following viruses: Yellow Fever 17 D, West Nile, EMC, Polio type 2 (mouse-adapted), Herpes simplex and ECHO type 9.

Footnotes

¹ Present address: Department of Microbiology, College of Medicine, University of Florida, Gainesville, Florida.

² Present address: Virus Division, Evans Medical Ltd., Speke, Liverpool, Great Britain.

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