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Demonstration of Human Measles Antibody by Mixed Agglutination¹

From the Department of Bacteriology and Immunology and the Department of Pediatrics, School of Medicine, State University of New York at Buffalo, Buffalo, New York

Abstract

1. A method for the demonstration of human measles antibody by mixed agglutination was developed. The antibody attached to cells infected with measles virus and was detected by erythrocytes bound through an anti--globulin antibody bridge.

2. The mixed agglutination method was compared to hemagglutination-inhibition and complement-fixation tests and reasonable agreement was obtained. More positive results and higher antibody titers were obtained by mixed agglutination.

3. Several types of studies were employed to evaluate the mixed agglutination method including: a) detection of measles antibody in acute and convalescent sera from patients with clinical measles, b) antibody response as a result of immunization with measles vaccine, and c) occurrence of measles antibody in different age groups.

Footnotes

¹ This study was aided by Grant AI 04372-02 from the National Institutes of Health.

² United States Public Health Service Research Career Award (AI-K6-1136).