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The Detection of Humoral Antibodies Directed against Salicylates in Hypersensitive States¹

From the Departments of Microbiology and Medicine Wayne State University College of Medicine Detroit, Michigan

Abstract

Conjugates of aspirin have been prepared which are able to stimulate antibody production in rabbits and sensitize guinea pigs to fatal anaphylactic shock. In addition, the indirect hemagglutination technique has been modified so that tanned sheep red blood cells treated with aspiryl-conjugates are able to combine with antibodies in the serum of individuals clinically sensitive to aspirin and para-aminosalicylic acid.

Footnotes

¹ This investigation was supported in part by a research grant from the National Science Foundation.

Portions of this paper were presented to the American Association of Immunologists at Chicago, Illinois, 1960.