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Studies on the Role of Complement in the Immune Clearance of Escherichia Coli and Rat Erythrocytes by the Reticuloendothelial System in Mice¹

From the Departments of Medicine and Pathology, New York University-Bellevue Medical Center, New York, New York

Abstract

The role of C' in the immune clearance of sensitized E. coli and sensitized rat erythrocytes by the reticuloendothelial system of the liver and spleen is demonstrated in mice:

1. Decomplemented mice are no longer able to eliminate rapidly antibody coated E. coli and rat erythrocytes from the blood.

2. In vitro incubation of sensitized E. coli (37°C) and rat erythrocytes (0°C) with fresh mouse serum as source of C' leads to full opsonized particles which can be equally well phagocytized by normal and decomplemented mice.

3. Pepsin and papain digestion of rabbit immune globulins resulted in loss of opsonic activity.

Footnotes

¹ This work was supported by grants No. A-3777 and A-4819 of the United States Public Health Service.

² Postdoctoral fellow of graduate training program 2A-5282.

³ Investigatorship of the Health Research Council of the City of New York under contract No. 1-124.

⁴ Investigatorship of the Health Research Council of the City of New York under contract No. 1-138.