HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Schmidt, N. J. Articles by Lennette, E. H. Search for Related Content PubMed PubMed Citation Articles by Schmidt, N. J. Articles by Lennette, E. H.

Serologic Reactivity of Certain Antigens Obtained by Fractionation of Coxsackie Viruses in Cesium Chloride Density Gradients¹

From the Viral and Rickettsial Disease Laboratory, California State Department of Public Health, Berkeley 4, California

Abstract

Cesium chloride density gradient centrifugation of certain Coxsackie viral types has served to separate the precipitating antigens possessing "specific" and "group" reactivity with human sera, and has also separated two complement-fixing (CF) antigens. One of the CF antigens (in the same fraction as the "specific" precipitating antigen) fixes complement with homotypic monkey immune serum, but not with human sera. The other CF antigen (in the same fractions as the "group" precipitating antigen) fixes complement with homotypic monkey immune serum and also with human sera from both homotypic and heterotypic Coxsackie virus infections. Heating at 56°C for 30 min converted the serologic activity of the fraction with "specific" precipitating activity and no CF activity with human sera to that of the fractions containing "group" precipitating activity and CF activity with homotypic and heterotypic human sera.

Footnotes

¹ The work on which these observations are based was supported by Grant E-1475 from the National Institute of Allergy and Infectious Diseases, National Institutes of Health, USPHS.