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Leukocyte Agglutination in Mice

Detection of H-2 and Non-H-2 Isoantigens¹

From the Departments of Medicine and Genetics, Stanford University School of Medicine, Palo Alto, California

Abstract

Development of a method for the detection of H-2 and non-H-2 isoantigens with the leukocyte agglutination reaction is described. Non-H-2 leukocyte agglutinins were induced by sensitization with injections of living spleen and thymus cells, by pregnancy and by skin homografts. Cross reaction of non-H-2 antisera with leukocytes of many inbred mouse strains was observed, indicating that these strains share some of the non-H-2 isoantigens. Selective in vivo absorption was done with one non-H-2 antiserum and a minimum of two separate agglutinating factors was found.

Footnotes

¹ This work supported in part by Grant C-4681 from the National Cancer Institute and Grant A-4514 from the National Institutes of Arthritis and Metabolic Diseases, National Institutes of Health, USPHS.

² Postdoctoral Fellow, Arthritis and Rheumatism Foundation, 1961 to 1962, Department of Medicine, Stanford University School of Medicine, Palo Alto, California.