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Studies of - and _2A-Globulins

Comparison of Immunochemical Properties of S and F (Papain) Fragments of Myeloma Proteins from Inbred Mice

From the Metabolism Service, National Cancer Institute, National Institutes of Health, Bethesda, Maryland

Abstract

The immunochemical properties of proteins formed in plasma cells of inbred mice were studied by comparison of intact molecules and S and F (papain-produced) fragments of - and _2A-myeloma proteins from BALB/c and C₃H/He mice.

Mouse _2A-myeloma proteins were reduced to two antigenically different classes of fragments (S and F). Each molecule appeared to contain two S and one F piece. The F fragments of the _2A-myeloma proteins could be crystallized.

Antigenic determinants specific for _2A-globulins were found on the F fragments. The antigenic determinants common to both the and _2A-globulins were found on the S fragments of both globulin types.

Two -myeloma proteins from BALB/c plasma cell tumors were found to have distinctive as well as common antigenic determinants. The antigenic differences were located in both the S and F fragments.