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Experimentally Induced Alterations of the Bactericidal Property of Rabbit Serum for Bacillus Subtilis

I. Effects of Total Body X-Ray Irradiation, Intravenous Administration of Immune Platelet Serum, Thorotrast and Intraperitoneal Injection of Endotoxin¹

From the Department of Medicine, The University of Rochester School of Medicine and Dentistry, Rochester, New York

Abstract

The bactericidal property of rabbit serum consists of two protein components derived from rabbit platelets. These are designated components 1 and 2. Total body x-ray irradiation of 700 r causes a striking reduction of platelets and of components 1 and 2. As little as 100 r of x-ray irradiation produce a decrease of component 1 without causing a decrease of the platelets.

Specific antiserum for rabbit platelets causes a rapid decrease in platelets and in components 1 and 2, when injected intravenously into rabbits. Studies in vitro reveal that normal rabbit serum loses its bactericidal property when antiplatelet serum is added. Highly bactericidal rat serum is not inhibited by anti-rabbit platelet antibody.

Intravenous injection of thorotrast into rabbits causes a precipitous decrease in platelets and of components 1 and 2 without producing any decrease in leukocytes or hematocrit.

Footnotes

¹ Supported by Grants A-1172 and 2A-5188 from the National Institute of Arthritis and Metabolic Diseases, USPHS, and by Grant CRMC 24, The National Foundation.