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Further Observations on the Serologic Specificity of Sialic Acid for Rh_o(D) Antibody¹

From the Department of Microbiology, Ohio State University, Columbus, Ohio

Abstract

The previous work showing that certain crude preparations of N-acetylneuraminic acid (NANA), a brain ganglioside containing NANA, and degradation products such as N-acetylglucosamine and mannosamine specifically inhibited Rh_o(D) antibody has been found to be dependent on factors such as the time of incubation of inhibitor and antiserum, the amount of antibody used and the nature of the preparation. Absorption of anti-D serum with D-negative cells to which these substances had been coupled demonstrated that NANA from human plasma which did not inhibit, and poor inhibitors such as N-acetylglucosamine, bound anti-D and removed it from serum as efficiently as good inhibitors.

Footnotes

¹ This work was supported by Grant E-3887 from the National Institute of Allergy and Infectious Diseases.

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