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Antigenicity of Polypeptides (Poly--Amino Acids)

VIII. Studies in Guinea Pigs¹

From the Department of Microbiology, Seton Hall College of Medicine and Dentistry, Jersey City 4, New Jersey

Abstract

It has been demonstrated that although the response in guinea pigs is variable, the polymers GLA5, GLT, GLPhe, GLA30, GLAT and GAT are antigenic. Both early (immediate) and late (delayed) skin reactions were noted. GLA30 and GLAT produced the most extensive reactions.

From cross PCA reactions, it was determined that most of the specificity in GLA5, GLPhe and GLT is the same as in GL but that GLT also has a GT specificity. In GLA30 and GLAT, in addition to the above specificity, there is also a GA specificity.

Footnotes

¹ This work was supported by Grants E 3514 and 2E 196 from the National Institutes of Allergy and Infectious Diseases and Contract No. DA-49-193-MD-2113 from the Department of the Army. Office of the Surgeon General. Presented in part at the annual meeting of the American Association of Immunologists, Atlantic City, New Jersey, 1961, and at the First International Symposium on Poly Alpha Amino Acids, Madison, Wisconsin. June 1961.