HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Maurer, P. H. Articles by Pinchuck, P. Search for Related Content PubMed PubMed Citation Articles by Maurer, P. H. Articles by Pinchuck, P.

Antigenicity of Polypeptides (Poly--Amino Acids)

VI. Studies in Rabbits¹

From the Department of Microbiology, Seton Hall College of Medicine and Dentistry, Jersey City 4, New Jersey

Abstract

The interrelationships among a group of linear copolymers containing the amino acids, glutamic acid, lysine, alanine, tyrosine and phenyl alanine have been shown. The introduction of 5 moles % alanine into GL did not change the specificity of the molecule but the introduction of 30 moles % alanine (GLA30) resulted in a copolymer causing the production of antibody with a reactivity for all polymers listed in this study. The introduction of tyrosine into G-L (5 moles %) or G-A (10 moles %) led to antigens with some specificity directed against tyrosyl groupings, but not with enhanced antigenicity. Specificity against polyglutamic acid groupings was shown by the PCA reaction. Some heterogeneity in antibody response against the polymers has been shown by studies of diffusion in agar.

Footnotes

¹ This work was supported by Grants E 3514 and 2E 196 from the National Institute of Allergy and Infectious Disease and Contract No. DA-49-193-MD-2113 from the Department of the Army, Office of the Surgeon General.

Presented in part at the annual meeting of the American Association of Immunologists, Atlantic City, New Jersey, April 1961, and at the First International Symposium on Poly Alpha Amino Acids. Madison, Wisconsin, June 1961.