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The Effect of Methotrexate on the Production of Antibodies against Attenuated Distemper Virus in the Dog¹

From the Mary Imogene Bassett Hospital (Affiliated with Columbia University) Cooperstown, N.Y. and Veterinary Virus Research Institute, Cornell University, Ithaca, New York

Abstract

Methotrexate is a potent inhibitor of antibody production in the dog at dose levels that are not in themselves productive of serious toxicity. In the absence of antibody production inoculation with the attenuated virus of distemper vaccine causes a fatal illness. The production of a fatal illness by this usually benign vaccine virus illustrates the heightened hazard of infection in subjects whose immunologic responsiveness is reduced by chemotherapy.

Footnotes

¹ Supported by Research Grants A2215 and C2643 from the United States Public Health Service and by Contract AT(30-1)-2005 from the United States Atomic Energy Commission.