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The Temporal Relationship of Acquired Tolerance and the Immune Response Following Injection of Bovine Serum Albumin into Neonatal Mice¹

From the Department of Physiology, Stanford University, Stanford, California

Abstract

In the present study the temporal relationship of acquired immune tolerance and the immune response was determined in mice injected at birth with BSA. It was found that both were finite in time and that their degree and duration were determined by the amount of BSA injected. The results also demonstrated that the acquired tolerance and the immune response that followed were due to the same antigen.

Footnotes

¹ This work was supported by Grant E-3733 from the U. S. Public Health Service.

² U. S. Public Health Service Research Career Development Awardee (GM-K3-5794-C1).