HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Jensen, M. M. Articles by Rasmussen, A. F. Search for Related Content PubMed Articles by Jensen, M. M. Articles by Rasmussen, A. F.

Stress and Susceptibility to Viral Infections

II. Sound Stress and Susceptibility to Vesicular Stomatitis Virus¹

From the Division of Virology, Department of Infectious Diseases, University of California Medical School, Los Angeles 24, California

Abstract

The susceptibility of mice to intranasally inoculated vesicular stomatitis virus was significantly altered by daily exposure to 3-hr periods of high intensity sound (123 db). Animals inoculated before and after the first period of stress showed an increase in susceptibility. Adrenalectomized mice inoculated on the 2nd day of stress responded in a like manner. Susceptibility of intact mice inoculated on days subsequent to the first was biphasic. Animals inoculated before stress were more susceptible, whereas those inoculated after were more resistant to the virus than the controls. Daily stress subsequent to the day of inoculation further influenced susceptibility.

The increase in susceptibility was independent of adrenal functions. The refractory phase appeared to be related to adrenal activity.

Footnotes

¹ Supported by grants from National Institutes of Allergy and Infectious Diseases and of Mental Health, USPHS.

² Predoctoral Trainee, Mental Health Training Program, USPHS, 2M-6415. Present address: Research Service, Veterans Administration Center, Los Angeles 25, California.

This article has been cited by other articles:

				V Riley Psychoneuroendocrine influences on immunocompetence and neoplasia Science, June 5, 1981; 212(4499): 1100 - 1109. [Abstract] [PDF]