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Immunologic Paralysis Produced in Mice by Klebsiella Pneumoniae Type 2 Polysaccharide¹

From the Department of Microbiology, Tulane University, School of Medicine, New Orleans, Louisiana

Abstract

Mice injected with varying amounts of Klebsiella pneumoniae type 2 polysaccharide were subsequently challenged with living homologous organisms after varying intervals of time. Of three preparations of polysaccharide, one was essentially nontoxic and nonimmunizing; the other two were approximately equal in antigenicity. In the groups of animals receiving 2.5 µg of these latter preparations, there was a greater proportion of survivors than in groups given 750 µg. Passively protective antibodies were detected within 5 days in the serum of mice given 2.5 µg, whereas in the serum of animals given 750 µg of polysaccharide such antibodies were not evident before 60 days—a time when the degree of active protection in comparable animals was waning.

Footnotes

¹ This work was supported by U.S.P.H.S. Research Training Grant 2G-79 and N.S.F. Research Grant G 5020.

² Now in Pathology Laboratories, Decatur and Macon County Hospital, Decatur, Ill.

³ Now in Division of Biologics Standards, National Institutes of Health, DHEW, Bethesda 14, Md.