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Studies on the Antibacterial Action of Human Saliva

III. Cofactor Requirements of a Lactobacillus Bactericidin¹

From the School of Dentistry, University of Washington, Seattle, Washington

Abstract

The cofactor necessary for the activation of a salivary bactericidin active against Lactobacillus acidophilus ATCC 4357 was identified both in vitro and in vivo as thiocyanate. Although iodide in sufficient concentration would also substitute for the cofactor, the amount required was incompatible with the concentration found in saliva.

Footnotes

¹ This investigation was supported by U.S.P.H.S. Research Grant D-771 from the National Institute of Dental Research, National Institutes of Health.