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Studies in Specific Hypersensitiveness

XI. The Familial Occurrence of Hay Fever and Bronchial Asthma¹

From the Department of Bacteriology and Immunology, Division of Immunology in Cornell University Medical College, and of the First Medical division in the New York Hospital

Abstract

In their work upon human sensitization, in 1916, Cooke and Vander Veer (1) included a study of inheritance in a group of 504 cases of atopy² This group comprised cases of hay fever, bronchial asthma, urticaria, angioneurotic edema and acute gastroenteritis following the ingestion of fish and strawberries. These authors stated that their study indicated a definite hereditary factor in hypersensitiveness as shown particularly by the influence of heredity on the age of onset of clinical symptoms. The present study was undertaken to determine whether or not their results would be verified on an entirely new series. Five hundred sixty-eight cases of hay fever and asthma are now presented, in all of which the hypersensitive condition was demonstrated by a positive intradermal test which was in complete accord with the clinical history.

Footnotes

¹ The tenth paper of this series is the unnumbered article by Coca and Cooke published in this Journal, 1923, 8, 163.

² The term "atopy" has been suggested by Coca and Cooke to designate inherited human hypersensitiveness (Coca, A. F., and Cooke, R. A., Jour. Immunol., 1923, 8, 166).