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The Production of Precipitins for Ragweed Pollen

From the Department of Bacteriology and the Department of Pathology, College of Physicians and Surgeons, Columbia University, New York

Abstract

It has been proved beyond question that guinea-pigs can be made hypersensitive to pollen (ragweed or rye) (1, 2, 3, 4). However, because of the failure of all workers to demonstrate precipitins to pollens, certain observers (1, 3, 5, 6) still hold that the specific hypersensitive condition brought about by the injection of pollen into guinea-pigs may not be a true anaphylactic sensitization. Although Alexander (12), in one instance, was able to transfer the hypersensitive condition to rye pollen, passively, he was unable to demonstrate precipitins in the serum of the 4 guinea-pigs tested.

In this paper, we are reporting on the results of the successful production of precipitins for ragweed pollen.

Experimental Method of immunization. We were entirely unsuccessful in demonstrating precipitins in the serum of 2 rabbits injected weekly for a period of over two months with a suspension or a weak alkali extract of giant ragweed pollen.