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The Toxicity of Human Blood Plasma Obtained in Various Diseases

IV. Studies on the Toxicity of Human Blood Plasma for Guinea-Pigs

From the Laboratories of the Municipal Tuberculosis Sanitarium, and the Department of Pathology, University of Illinois, College of Medicine, Chicago, Illinois

Abstract

In a recent report of the subject on the toxicity of human blood plasma for guinea-pigs we (1) discussed the question of the relative toxicity of fetal and maternal blood plasmas. In association with these studies the question of the toxicity of blood before, during, and after menstruation was also considered. It was believed at that time that when the blood plasmas from these conditions were injected into a guinea-pig which has not been previously sensitized to a foreign protein that death resulting would be due to an intravascular coagulation. This we have discussed under the question of coagulation toxicity.

In an analysis of the subject under consideration it was believed that the intravascular coagulation which produced the shock and finally death of the animal was in relationship with the quantitative increase of fibrinogen in the plasma. When the fibrinogen content of the above mentioned cases was determined it was found that there was a quantitative increase of fibrinogen over normal.