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The Gradual Decrease of the Active Immunizing Value of Toxin-Antitoxin Mixtures Stored During One Year

From the Research Laboratories of the Department of Health, New York City

Abstract

About two years ago when the active immunization from the 3 and 5 L+ toxin-antitoxin mixtures were compared the results showed that the 5 L+ did not give any greater percentage of active immunity in children than the 3 L+. The 5 L+ however, did give a higher percentage of local and constitutional reactions in children and adults. These were due to the greater amount, of protein substances in the mixture. The 5 L+ mixtures were made with the aged diphtheria toxin without any dilution other than that due to the addition of the proper amount of antitoxin, whereas the 3L+ mixtures were prepared from the 5 L+ toxin, diluted with water to contain 3 L+ and therefore had 40 per cent less of the reacting substances. Even with this lesser amount of reacting substances, the 3 L+ mixtures gave annoying reactions.